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GHK-Cu Skin & Hair Density Protocol
Skin matrix support and scalp/hair density
Overview
GHK-Cu is used two distinct ways in enthusiast practice: as a topical serum/cream for skin, or via injection/microneedling to the scalp for hair-density goals. The two use-cases have very different dosing conventions — this entry covers both, listed separately.
Dosing schedule
Informational only — not medical advice.
| Phase | Amount | Frequency | Timing | Route |
|---|---|---|---|---|
| Topical — skin | 2–3% solution | 1x/day | PM | topical |
| Scalp — microneedled/injected | 1–2 mg per session | 1–2x/week | — | subcutaneous injection |
Administration
Topical: apply to clean, dry skin. Injectable/scalp use: reconstitute with bacteriostatic water; many users combine with microneedling for scalp delivery rather than a plain injection.
Cycle length
12 weeks on. Skin/hair endpoints are slow — most protocols run continuously for a minimum 8–12 week block before assessing effect.
Precautions
- Copper peptides can cause contact irritation in some users — patch-test topical use first.
- Avoid combining high-dose oral vitamin C or strong antioxidant serums immediately before/after topical application (may reduce stability).
- No controlled long-term safety data for chronic injectable/scalp use.