NAD+ Cellular Energy & Longevity Protocol
Mitochondrial/cellular energy support and longevity-adjacent use
Overview
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to cellular energy metabolism that declines with age, and is one of the most discussed compounds in the self-directed longevity community. It is most often associated with clinic-administered IV infusions, but self-administered subcutaneous protocols are common in enthusiast circles at lower per-dose amounts.
Dosing schedule
Informational only — not medical advice.
| Phase | Amount | Frequency | Timing | Route |
|---|---|---|---|---|
| Weeks 1–2 (titration) | 25–50 mg | Daily or every other day | Inject slowly, over several minutes | subcutaneous injection |
| Maintenance | 50–100 mg | 3–5x/week | — | subcutaneous injection |
Administration
Reconstitute with bacteriostatic water. Injection speed is the single most important variable — inject slowly (several minutes, or split into smaller sub-doses given in sequence) since rapid administration is strongly associated with facial flushing, chest tightness, and nausea. Many users start at the low end of the range and titrate up as tolerability is established.
Cycle length
12 weeks on. Often run continuously/long-term rather than in short cycles, consistent with its use as a longevity-oriented compound rather than an injury-recovery one.
Precautions
- Flushing, chest tightness, and nausea are common with fast injection/infusion — slow administration is the primary mitigation, not a lower dose.
- Limited long-term controlled-trial safety data for chronic self-administered subcutaneous use specifically (most rigorous data is from clinic-administered IV contexts).
- Discontinue and seek medical attention for severe chest pain, difficulty breathing, or signs of allergic reaction.
- Theoretical caution for anyone with a history of cardiac arrhythmia, given reported chest-tightness/palpitation sensations during rapid administration — check with a physician first.